A novel tumor targeted drug delivery system (TTDDS) for improved specificity and efficacy

A novel tumor targeted drug delivery system (TTDDS) for improved specificity and efficacy

BACKGROUND 

Combination therapy is the primary treatment option against cancer, because multiple agents in combination, synergistically improve efficacy and are less prone to resistance due to their distinct action mechanisms. Despite these advantages, lack of tumor specificity continues to be a serious issue in combination therapy, thus resulting in a need to develop an efficient vehicle for targeted drug delivery.

DESCRIPTION 
Dr. Iwao Ojima, Distinguished Professor and colleagues at Stony Brook University have invented a robust tumor targeted drug delivery system (TTDDS) that consist of (a) triazine based tripod splitter module (b) two-drug payload feature (c) self immolative disulfide linkers for drug release, and (d) PEG linkers to improve solubility. Using biotin as a tumor targeting moiety and taxoid-camptothecin combination in the TTDDS, our invitro data demonstrates a twofold improvement in selectivity and a cooperative effect in efficacy.
ADVANTAGES 

Applicable to a variety of two drug combinations l Amenable to fluorescent coupling and PET, SPECT, and MRI imaging l Deliver two different drugs to a tumor

APPLICATION 

Tumor-targeting drug delivery and diagnosis

ADDITIONAL INFORMATION 

Further reading: (1) Vineberg et al., J. Med. Chem. 2014; 57, 5777-91 (2) Vineberg et al., J. Med. Chem. 2015; 58, 2406-16 (3) Seitz et al., Bioorg. Med. Chem., 2015; 23, 2187-94

DEVELOPMENT STAGE 
In vitro studies
PATENT STATUS 

US Utility Pending (# 15/127,083)

ADDITIONAL INFORMATION

INVENTORS 

Iwao Ojima Ph. D.
Distinguished Professor

Jacob Vineberg
Grad Research Assistant

Tao Wang

CASE MANAGER 
Anupam Jhingran
LICENSING STATUS 

Available for License

LICENSING POTENTIAL 
We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.
TECHNOLOGY ID 
8613
PRIMARY KEY 
841775
KEYWORDS 

Trazine l Linker l Drug delivery l Tumor targeting l Cancer imaging

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