Dendrimer based platform technology for tumor targeting, drug delivery and imaging

Dendrimer based platform technology for tumor targeting, drug delivery and imaging

BACKGROUND 

Dendrimers are nano-sized globular macromolecules that have been well studied as a drug delivery vehicles. Their convenient synthesis strategy, easy functionalization of the terminal end group and versatility in designing, make dendrimers such as PAMAM, a choice for drug carrier. Additionally dendrimers as macromolecular carrier have large loading capacity to achieve high concentration at tumor sites. Therefore a controlled strategy to functionalize dendrimers with multiple molecules such as targeting module, cytotoxic drug and/ or fluorescent moiety coupled with their purification strategy that achieves batch to batch consistency is critical for fully exploiting the field of dendrimer based tumor targeting.

DESCRIPTION 
To overcome the inconsistency associated with multi-functionalization of dendrimers, Dr. Ojima, a Distinguished Professor at Stony Brook University, and his team developed an asymmetric bow-tie dendrimer construction strategy. Using this strategy we developed and tested the efficacy of a novel bow-tie dendrimer, bearing a PEGylated spacer that improve solubility, vitamin as a tumor targeting module and a new generation toxoid. In summary, this technology introduces novel multifunctional asymmetric bow-tie dendrimers as a robust platform for drug delivery systems and diagnostic agents.
ADVANTAGES 

High loading capacity l Increased concentration at target sites l Allows controlled functionalization of dendrimer surface l Robust chemistry and batch-to-batch consistency

APPLICATION 

Drug delivery l Therapeutics l Imaging l Research

DEVELOPMENT STAGE 
In vitro data is available
PATENT STATUS 

Utility application pending (#14/917,344)

ADDITIONAL INFORMATION

INVENTORS 

Iwao Ojima Ph. D.
Distinguished Professor and Director

Yu Han Gary Teng

Tao Wang

CASE MANAGER 

Valery Matthys, Ph. D.
valery.matthys@stonybrook.edu
6316326561

LICENSING STATUS 

Available for License

LICENSING POTENTIAL 
We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.
TECHNOLOGY ID 
8573
PRIMARY KEY 
520874
KEYWORDS 

Drug Delivery l Imaging l Poly amido amine PAMAM l diagnosis l Multifunctional dendrimers

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