Microfluidic device for true single-cell encapsulation

Dr. Eric Brouzes has developed an innovative device for the preparation of precious samples for single cell analysis with microfluidics droplets. The device is based on a series of encapsulation modules comprised of overhang structures prior to a typical trapping chamber. overhanging structures are placed to steer cells towards the capturing streamlines, resulting in an efficient single-cell trapping (99%) while ensuring good compatibility with the encapsulation step. Dr. Brouzes has shown success rates of cell encapsulation reach 86% for fixed cells and 78% for live cells. No empty droplets are generated during the encapsulation step and most contain a single cell (99% of droplets for fixed cells).