A novel PET imaging agent for diagnosing bacterial infections

A novel PET imaging agent for diagnosing bacterial infections

BACKGROUND 

Bacterial infections such as those of prosthetic joints, bones (osteomyelitis) and heart valves (infective endocarditis) are difficult to diagnose and treat, and are a major cause of mortality, morbidity and health care costs. PET is a promising, non-invasive imaging technique for detecting and localizing infections in humans. Most of the current PET studies rely on FDG, however, this tracer lacks specificity since it can be taken up by host inflammatory cells as well as bacterial cells at the site of infection. Consequently, there is a need to develop sensitive and specific PET radiotracers that can identify bacterial infections.

DESCRIPTION 
Dr. Peter Tonge at SBU in collaboration with colleagues from Johns Hopkins University have synthesized and examined a novel PET tracer, [18F]F-PABA which, (unlike FDG) is taken up only by bacterial cells thus making it specific for diagnosing infection. In addition, our inventors have also identified a novel chemical synthesis method for high radiochemical yield of [18F]F-PABA. Given the specificity of [18F]F-PABA to differentiate between the bacterial infection from sterile inflammation coupled with high yield synthesis method to produce this tracer, our technology offers an excellent tool in the space of bacterial infections diagnostics. Second generation tracers are currently under development.
ADVANTAGES 

PET tracer that differentiates bacterial infection from sterile inflammation l Readily synthesized with high radiochemical yield l High signal-to-noise ratio l Quantify bacterial burden l Applicable for many bacterial infections.

APPLICATION 

Infectious diseases l Diagnostics l PET imaging l Radiotracers

DEVELOPMENT STAGE 
Preclinical studies
PATENT STATUS 

Pending US and provisional applications covering compositions, chemical synthesis and methods of use

ADDITIONAL INFORMATION

INVENTORS 

Peter Tonge Ph. D.
Professor

Zhuo Zhang
Student

Peter Smith-Jones Ph. D.
Professor

Hui Wang
Student

Li Liu Ph. D.
Research Assistant Professor

CASE MANAGER 

Valery Matthys, Ph. D.
valery.matthys@stonybrook.edu
6316326561

LICENSING STATUS 

Available for License

LICENSING POTENTIAL 
We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.
TECHNOLOGY ID 
8867
PRIMARY KEY 
1671821
KEYWORDS 

PET Tracers l FDG l PABA l Bacterial infections

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